Why is Brainol™ So Effective?

Doctor Formulation

Brainol™ is a breakthrough proprietary supplement that effectively combines the most powerful and extensively researched ingredients, giving you a dual action fuel and boost solution. Every single ingredient in was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help you reach your goals and succeed more effectively than any other cognitive enhancing supplement available.

Brainol™ contains 18 tested ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close to in terms of quality and purity of ingredients.

Recommended dose for adults is 2 (two) capsules daily with meals.

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Brainol™ 's - Proprietary Blend of Ingredients:

    Huperzine A is a plant based compound that has been found to enhance cognitive function, improve memory and has neuroprotective effects. Huperzine A is an inhibitor to the breakdown of the neurotransmitter, acetylcholine. Because of this, mechanisms of huperzine A are mostly described through the mechanisms of acetylcholine. Acetylcholine acts in the central nervous systems showing increased response to stimuli, expectation of uncertainty, and improved learning and plasticity. Another mechanism of huperzine A is blocking a receptor which allows the transfer of electrical signals from the brain to the spinal column.

    A recent study demonstrated results that showed 58 percent of the patients treated with Huperzine A had improvements in memory, cognition, and behavioural functions.

    *References:
  1. Xu ZQ1, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys. 2012 Jan;62(1):55-8.
  2. Sun QQ1, Xu SS, Pan JL, Guo HM, Cao WQ. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo Yao Li Xue Bao. 1999 Jul;20(7):601-3.
  3. Zhang RW1, Tang XC, Han YY, Sang GW, Zhang YD, Ma YX, Zhang CL, Yang RM. Drug evaluation of huperzine A in the treatment of senile memory disorders. Zhongguo Yao Li Xue Bao. 1991 May;12(3):250-2.
  4. L-Tyrosine is a multifaceted supplement promoted for applications as varied as stress relief to cognitive enhancement to fat burning to mood improvement. The effects of L-Tyrosine are so wide-ranging because it influences several brain systems at once. It is a non-essential amino acid used to manufacture a number of hormones and neurotransmitters including Dopamine, Norepinephrine, Epinephrine, and Thyroxine.

    In dopaminergic cells in the brain, tyrosine is converted to l-dopa by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into catecholamines, such as norepinephrine (noradrenaline) and epinephrine (adrenaline).

    *References:
  5. Deijen JB, Orlebeke JF (1994). "Effect of tyrosine on cognitive function and blood pressure under stress". Brain Res. Bull. 33 (3): 319–23.
  6. Lieberman HR, Corkin S, Spring BJ, Wurtman RJ, Growdon JH (1985). "The effects of dietary neurotransmitter precursors on human behavior". Am J Clin Nutr. 42 (2): 366–370.
  7. Magill RA, Waters WF, Bray GA, Volaufova J, Smith SR, Lieberman HR et al. (2003). "Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation". Nutritional Neuroscience 6 (4): 237–46.
  8. Thomas JR, Lockwood PA, Singh A, Deuster PA (1999). "Tyrosine improves working memory in a multitasking environment". Pharmacol. Biochem. Behav. 64 (3): 495–500.
  9. L-Theanine is an amino acid analogue of the proteinogenic amino acids and is found primarily in particular plant and fungal species. It was discovered as a constituent of green tea and is absorbed in the small intestine after oral ingestion.

    Able to cross the blood–brain barrier, theanine has reported psychoactive properties. Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition and boost mood and cognitive performance in a synergistic manner with caffeine.

    *References:
  10. Gomez-Ramirez, Manuel; Higgins, Beth A.; Rycroft, Jane A.; Owen, Gail N.; Mahoney, Jeannette; Shpaner, Marina; Foxe, John J. (2007). "The Deployment of Intersensory Selective Attention". Clinical Neuropharmacology 30 (1): 25–38.
  11. Kimura, Kenta; Ozeki, Makoto; Juneja, Lekh Raj; Ohira, Hideki (2007). "L-Theanine reduces psychological and physiological stress responses". Biological Psychology 74 (1): 39–45.
  12. Park, Sang-Ki; Jung, In-Chul; Lee, Won Kyung; Lee, Young Sun; Park, Hyoung Kook; Go, Hyo Jin; Kim, Kiseong; Lim, Nam Kyoo et al. (2011). "A Combination of Green Tea Extract andl-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study". Journal of Medicinal Food 14 (4): 334–43.
  13. Vitamin B Complex Blend contains B6, B12, B1, B2 and B3. All B vitamins are responsible for important functions including contributing to nerve health, heart and blood health, skin and eye health, reducing inflammation, hormonal function, and are used to maintain a healthy metabolism and digestive system. They support healthy blood flow, oxygenation, and energy production in the brain.

    B6 increases energy, regulates mood and proper brain development. Researchers found that Vitamin B6 plays an important role in the production of serotonin and dopamine, which are necessary for nerve communication.

    B12 decreases fatigue, lethargy and stress. It is a vital nutrient essential for everyone including older adults. As per recent research, adequate amount of B12 can prevent mental decline. Experts found that patients experiencing memory problems, when treated with B12, many symptoms disappeared within 6 months accompanied by improvements in mental clarity and focus.

    B1 Thiamine is used in the biosynthesis of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). The brain requires a much greater amount of thiamine than in other cells of the body and deficiencies can lead to detrimental neurological effects if not present in the diet.

    B2 Riboflavin deficiency may result in subtle neuropsychological impairment. It is needed for the function of every single cell in the body and brain.

    B3 Niacin deficiency symptoms include irritability, poor concentration, anxiety, fatigue, restlessness, apathy, and depression. Niacin also appears to up-regulate brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) expression.

    *References:
  14. Ebben M, Lequerica A, Spielman A. Effects of pyridoxine on dreaming: a preliminary study. Percept Mot Skills. 2002 Feb;94(1):135-40.
  15. Lerner V, Miodownik C, Kaptsan A, Bersudsky Y, Libov I, Sela BA, Witztum E. Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind, placebo-controlled, crossover study J Clin Psychiatry. 2007 Nov;68(11):1648-54.
  16. Mahan, L. K.; Escott-Stump, S., eds. (2000). Krause's food, nutrition, & diet therapy (10th ed.). Philadelphia: W.B. Saunders Company. ISBN 0-7216-7904-8.
  17. Combs, G. F. Jr. (2008). The vitamins: Fundamental Aspects in Nutrition and Health (3rd ed.). Ithaca, NY: Elsevier Academic Press. ISBN 978-0-12-183493-7.
  18. Prakash R, Gandotra S, Singh LK, Das B, Lakra A (2008). "Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy". General Hospital Psychiatry 30 (6): 581–4.
  19. Fu L, Doreswamy V, Prakash R (2014). "The biochemical pathways of central nervous system neural degeneration in niacin deficiency". Neural Regen Res 9 (16): 1509–1513
  20. D M Tucker, J G Penland, H H Sandstead, D B Milne, D G Heck, and L M Klevay. Nutrition status and brain function in aging. Am J Clin Nutr July 1990 vol. 52 no. 1 93-102
  21. Choline Bitartrate is a water-soluble essential nutrient discovered to increase the synthesis and release of acetylcholine by neurons, leading to an interest in dietary choline and brain function. Subsequent studies have shown an improvement in symptoms of Alzheimer's dementia, coordination of neurological symptoms, cognitive and emotional functions, activity and mood in patients with cerebrovascular disease.

    *References:
  22. De Jesus Moreno Moreno M Clin Ther. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. 2003 Jan;25(1):178-93.
  23. Canal N, Franceschi M, Alberoni M, Castiglioni C, De Moliner P, Longoni A. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol. 1991 Mar;29(3):103-7.
  24. DMAE is known to have effective transportation to the brain and can result in a higher level of Cholinergic activity. Once DMAE reaches the brain, it is methylated. This is a reaction that involves the addition of a methyl group to a compound, and this reaction produces choline. However, the choline produced by DMAE is charged and cannot penetrate the blood brain barrier. The DMAE is then instead bound to phospholipids in place of the choline, which produces phosphatidyl-dimethylaminoethanol. This is then utilised in nerve membranes to increase fluidity and permeability, and also acts as an antioxidant.

    Studies have found that DMAE improves memory, learning and concentration as well as having a net positive effect on intelligence. This is most likely due to the fact that it potentiates the synthesis of acetylcholine in the brain. Acetylcholine is a neurotransmitter that neurons use to communicate when consolidating, encoding and recalling memories. It also plays a role in our ability to focus as well as the plasticity of the brain. Higher levels of acetylcholine can lead to greater clarity of thought, memory retention, focus, and analytical skills.

    *References:
  25. Dimpfel W, Wedekind W, Keplinger I (May 2003). "Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states". Eur. J. Med. Res. 8 (5): 183–91.
  26. Knobel M (1974). "Approach to a combined pharmacologic therapy of childhood hyperkinesis". Behav Neuropsychiatry 6 (1–12): 87–90.
  27. Alpha Lipoic Acid has a strong ability to neutralize the damaging effects of oxidative stress and is the subject of intense study in preventing free radical damage to the neurological system.

    Lipoic acid is able to pass readily into the brain and reach all parts of a nerve cell. Experimental studies have shown that lipoic acid reduced brain damage after a stroke, and that those animals who received lipoic acid had a survival rate three times greater than those that did not. Some of the protective effects conferred by lipoic acid in promoting healthy nerve function may be related to its ability to regenerate the antioxidant glutathione, which is often significantly depleted by harmful oxidative stress associated with cerebrovascular events such as stroke.

    New evidence also suggests that lipoic acid may help guard against one of the most dreaded conditions associated with aging—Alzheimer's disease. Researchers have identified a series of mechanisms through which lipoic acid may work in helping prevent or manage Alzheimer's disease. Scientists believe that lipoic acid may increase the production of acetylcholine, an essential nervous system messenger that is deficient in the brains of Alzheimer's disease victims.

    *References:
  28. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78.
  29. Panigrahi M, Sadguna Y, Shivakumar BR, et al. alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996 Apr 22;717(1-2):184-8.
  30. Holmquist L, Stuchbury G, Berbaum K, et al. Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.
  31. Phosphatidylserine is essential to help brain neurons support and maintain memory function and neuroplasticity—the dynamic capacity to replace damaged neurons and to make new ones. Neuron-to-neuron communication and neuroplasticity depend on a steady supply of phosphatidylserine and other “smart" nutrients.

    In 2003, even the biased FDA granted “qualified health claim" status to phosphatidylserine, allowing supplement manufacturers to state that “consumption of phosphatidylserine may reduce the risk of dementia in the elderly" and “consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly."

    Studies suggest that phosphatidylserine can benefit people of all ages. In the middle-aged and the elderly, phosphatidylserine has been shown to prevent and restore memory loss and alleviate stress and anxiety. Preliminary research indicates that phosphatidylserine may also benefit children with attention, learning, or behavioral problems.

    *References:
  32. Kim H.Y., Huang B.X., Spector A.A. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18.
  33. Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC. Effects of phosphatidylserine in age-associated memory impairment. Neurology. 1991 May;41(5):644-9.
  34. Baumeister J, Barthel T, Geiss KR, Weiss M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. 2008 Jun;11(3):103-10.
  35. Phosphatidylserine. Monograph. Altern Med Rev. 2008 Sept;13(3):245-7
  36. Kidd PM. Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management. Altern Med Rev. 2000 Oct;5(5):402-28.
  37. Acetyl-L-Carnitine (ALCAR) is a compound used in the generation of metabolic energy and is a powerful antioxidant and reduces fatigue. Acetylcarnitine and carnitine play important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Therefore it serves as an energy reservoir of acetyl groups and both nutrients help improve energy production.

    Studies have shown that it decreases problems with attention and aggression in boys diagnosed with ADHD, improves concentration and mental fatigue in those with chronic fatigue syndrome, improves symptoms of autism spectrum disorders, improves recovery after exercise, improves mental and physical fatigue and status in the elderly, improves arterial hypertension, insulin resistance, and impaired glucose tolerance in those with increased cardiovascular risk.

    *References:
  38. Van Oudheusden LJ, Scholte HR. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2002 Jul;67(1):33-8.
  39. Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004 Mar-Apr;66(2):276-82.
  40. Geier DA, Kern JK, Davis G, King PG, Adams JB, Young JL, Geier MR. A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders.Med Sci Monit. 2011 Jun;17(6):PI15-23.
  41. Volek JS1, Kraemer WJ, Rubin MR, Gómez AL, Ratamess NA, Gaynor P. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E474-82.
  42. Malaguarnera M1, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):181-90. Epub 2007 Jul 20.
  43. Brahmi (Bacopa monnieri) is an herb that contains numerous psychoactive compounds, It increases brain function and memory. Brahmi has been extensively tested and proven as a memory and concentration enhancer. Results of a recent study showed that Brahmi reduced the time needed to learn a new task by almost half! Participants taking Brahmi mastered the exercise in as little as 6 days compared to 10 days for the control group.

    Furthermore, it improves working memory, speed of visual information processing, learning rate, memory consolidation, and anxiety. It improves cognitive function, depression, and anxiety and it improves memory acquisition and retention in the elderly.

    *References:
  44. Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Phytother Res. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. 2008 Dec;22(12):1629-34.
  45. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
  46. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008 Jul;14(6):707-13.
  47. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. 2010 Jul;16(7):753-9.
  48. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81.
  49. Guarana (Paullinia cupana) is widely employed as a stimulant, to relieve fatigue, boost energy, aid concentration and brighten mood. It naturally contains between 2.5 to 7 percent of caffeine. Additionally, guarana contains tiny amounts of theophylline and theobromine, which are similar to caffeine, although they exert subtly different effects on the body. Caffeine stimulates the central nervous system and is a cortical stimulant, thus moblizing brain function. It stimulates the flow of blood in the brain and increases secretion of the important neurotransmitter, serotonin.

    Guarana also contains molecules called tannins, which some say causes the caffeine in guarana to release slowly, producing a long-lasting energy plateau its long-lasting effects.

    Tests on humans determined that a 75 mg dose of dried extract could improve task performance and increase attention span for up to six hours. Other research suggests that adding guarana to a multivitamin can help young adults perform better at mental tasks and fight the mental fatigue associated with long periods of brainwork, like studying for finals.

    *References:
  50. Andrew Scholey, Isabelle Bauer, Chris Neale, Karen Savage, David Camfield, David White, Silvia Maggini, Andrew Pipingas, Con Stough, and Matthew Hughes. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation Nutrients. 2013 Sep; 5(9): 3589–3604.
  51. Johannes, Laura (March 2, 2010). "Can a Caffeine-Packed Plant Give a Boost?". The Wall Street Journal. p. D3.
    1. St. John's wort (Hypericum perforatum) is a shrubby plant with clusters of yellow flowers and is a native of Europe, Asia and Africa and the United States. It was used in ancient Greece to treat various nervous disorders. St. John's wort contains hypericin, hyperforin, and flavonoids. It also has antibacterial, antioxidant and antiviral properties. St. John's wort is known for its capacity to reduce symptoms of mild-to-moderate depression and as a protector of the neurotransmitters responsible for mood regulation, energy and concentration.

      *References:
    2. Briese V, Stammwitz U, Friede M, Henneicke-von Zepelin HH. Black cohosh with or without St. John's wort for symptom-specific climacteric treatment -- results of a large-scale, controlled, observational study. Maturitas. 2007;57:405-14.
    3. Gaster B, Holroyd J. St. John's wort for depression. Arch Intern Med. 2000;160:152-156.

    Ginkgo Biloba is often used for memory disorders including Alzheimer's disease. It is also used for conditions that seem to be due to reduced blood flow in the brain, especially in older people. These conditions include memory loss, headache, ringing in the ears, vertigo, difficulty concentrating, mood disturbances, and hearing disorders.

    A Cochrane meta-analysis of 33 trials concluded that ginkgo appears to be safe, and showed promising evidence of improvement of cognition and function among patients who received the herb.

    A randomized, placebo-controlled trial of the effects of ginkgo in healthy, noninstitutionalized adults without dementia or other known mental deficit, from six weeks of ginkgo therapy (180 mg per day) on several standardized neuropsychologic measures of memory and learning showed clinically significant cognitive benefits in healthy persons.
    *References:
  52. Mix JA, Crews WD Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol. 2002;17:267–77.
  53. Ernst E, Pittler MH. Ginkgo biloba for dementia. A systematic review of double-blind, placebo-controlled trials. Clin Drug Invest. 1999;17:301–8.